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Table 3 Contribution of CYP450 isozyme to T-2 toxin hepatic metabolism assessed by the TNR method

From: The roles of carboxylesterase and CYP isozymes on the in vitro metabolism of T-2 toxin

CYP isozyme type

CYP2C19

CYP 3A4

CYP2C9

CYP2B6

CYP2D6

CYP1A2

CYP2E1

Vm (nmol/T-2/min nmol protein)

0.86 ± 0.02

13.98 ± 3.46

0.47 ± 0.03

1.2 ± .02

1.73 ± 0.03

1.37 ± 0.05

1.41 ± 0.07

Percentage of total activity

0.63

89.70

1.72

0.69

0.63

3.01

3.62