Articles
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Citation: Military Medical Research 2024 11:18
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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is...
Citation: Military Medical Research 2024 11:17 -
Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the spec...
Citation: Military Medical Research 2024 11:16 -
Emerging roles of ADP-dependent glucokinase in prostate cancer
Citation: Military Medical Research 2024 11:15 -
CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD
Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance...
Citation: Military Medical Research 2024 11:14 -
Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological f...
Citation: Military Medical Research 2024 11:13 -
ADP-dependent glucokinase: the ancient, archaeal key to prostate cancer
Citation: Military Medical Research 2024 11:10 -
Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D
Citation: Military Medical Research 2024 11:9 -
In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy
Citation: Military Medical Research 2024 11:12 -
Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways
Citation: Military Medical Research 2024 11:11 -
Nickel’s carcinogenicity: the need of more studies to progress
Citation: Military Medical Research 2024 11:8 -
Antimicrobial resistance crisis: could artificial intelligence be the solution?
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be dev...
Citation: Military Medical Research 2024 11:7 -
Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations?
Citation: Military Medical Research 2024 11:6 -
Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses
Citation: Military Medical Research 2024 11:5 -
GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis
Citation: Military Medical Research 2024 11:4 -
Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies. However, its application to solid tumors presents significant challenges due to the limited accessib...
Citation: Military Medical Research 2024 11:3 -
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
Citation: Military Medical Research 2024 11:1 -
Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures
One-third of veterans returning from the 1990–1991 Gulf War reported a myriad of symptoms including cognitive dysfunction, skin rashes, musculoskeletal discomfort, and fatigue. This symptom cluster is now refe...
Citation: Military Medical Research 2024 11:2 -
Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box...
Citation: Military Medical Research 2023 10:68 -
The applied principles of EEG analysis methods in neuroscience and clinical neurology
Electroencephalography (EEG) is a non-invasive measurement method for brain activity. Due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals, EEG has aroused much i...
Citation: Military Medical Research 2023 10:67 -
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, whi...
Citation: Military Medical Research 2023 10:66 -
Pre-hospital application of REBOA for life-threatening hemorrhage
Citation: Military Medical Research 2023 10:65 -
ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
Cell metabolism plays a pivotal role in tumor progression, and targeting cancer metabolism might effectively kill cancer cells. We aimed to investigate the role of hexokinases in prostate cancer (PCa) and iden...
Citation: Military Medical Research 2023 10:64 -
Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, whi...
Citation: Military Medical Research 2023 10:63 -
Targeting NR1D1 in organ injury: challenges and prospects
Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian o...
Citation: Military Medical Research 2023 10:62 -
BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
Citation: Military Medical Research 2023 10:61 -
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocy...
Citation: Military Medical Research 2023 10:59 -
Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics
Citation: Military Medical Research 2023 10:60 -
From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning
Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB). Although the tuberculin skin test and interferon-gamma release assay can be used to diagnose LTBI, these methods can...
Citation: Military Medical Research 2023 10:58 -
Human urinary cells for functional wound healing with sweat gland restoration
Citation: Military Medical Research 2023 10:57 -
Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liv...
Citation: Military Medical Research 2023 10:56 -
Cognitive function among military veterans with STEM occupations
Citation: Military Medical Research 2023 10:55 -
Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases
Degenerative musculoskeletal diseases are structural and functional failures of the musculoskeletal system, including osteoarthritis, osteoporosis, intervertebral disc degeneration (IVDD), and sarcopenia. As t...
Citation: Military Medical Research 2023 10:54 -
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) in protecting hepatocytes and media...
Citation: Military Medical Research 2023 10:53 -
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory hematologic malignancies. However, progress is still hindered as...
Citation: Military Medical Research 2023 10:52 -
The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population age...
Citation: Military Medical Research 2023 10:51 -
How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology
In the United States (US), the Surveillance, Epidemiology, and End Results (SEER) program is the only comprehensive source of population-based information that includes stage of cancer at the time of diagnosis...
Citation: Military Medical Research 2023 10:50 -
Regulatory T cells in skin regeneration and wound healing
As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. To this end, multiple tissue-resi...
Citation: Military Medical Research 2023 10:49 -
Elucidating regulatory processes of intense physical activity by multi-omics analysis
Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, mili...
Citation: Military Medical Research 2023 10:48 -
White-light-induced synthesis of injectable alginate-based composite hydrogels for rapid hemostasis
Citation: Military Medical Research 2023 10:47 -
Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy
Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1...
Citation: Military Medical Research 2023 10:46 -
Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine
Integrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. In...
Citation: Military Medical Research 2023 10:45 -
Deep learning-based lung sound analysis for intelligent stethoscope
Auscultation is crucial for the diagnosis of respiratory system diseases. However, traditional stethoscopes have inherent limitations, such as inter-listener variability and subjectivity, and they cannot recor...
Citation: Military Medical Research 2023 10:44 -
Enhancing the clinical relevance of haemorrhage prediction models in trauma
Citation: Military Medical Research 2023 10:43 -
RARRES2’s impact on lipid metabolism in triple-negative breast cancer: a pathway to brain metastasis
Citation: Military Medical Research 2023 10:42 -
Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities
Climate change profoundly shapes the population health at the global scale. However, there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease ...
Citation: Military Medical Research 2023 10:41 -
Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabeti...
Citation: Military Medical Research 2023 10:37 -
Bioengineered skin organoids: from development to applications
Significant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into c...
Citation: Military Medical Research 2023 10:40 -
Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer
Citation: Military Medical Research 2023 10:39 -
Spatial transcriptomics: recent developments and insights in respiratory research
The respiratory system’s complex cellular heterogeneity presents unique challenges to researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) have provided insights i...
Citation: Military Medical Research 2023 10:38
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- ISSN: 2054-9369 (electronic)