Fig. 1

In diabetic cardiomyopathy, interleukin-1 receptor associated kinase 2 (Irak2) translocates in the mitochondrion, where it triggers the recruitment of optic atrophy protein 1 (Opa1, also known as dynamin-like 120 kD protein) from the cristae junctions by prohibitin, destabilizing the organelle integrity and impairing its function. Complement factor D (Adipsin) inhibits the mitochondrial translocation of Irak2, eventually attenuating myocardial dysfunction