Table 2 The overview of NR1D1 ligands
From: Targeting NR1D1 in organ injury: challenges and prospects
Category | Ligands | Agonist or antagonist | Discoverer | Discovered year | References |
|---|---|---|---|---|---|
Endogenous | Heme | Agonist | Srilatha Raghuram | 2007 | [80] |
Synthetic | GSK4112 | Agonist | Qing-Jun Meng | 2008 | [81] |
Synthetic | SR8278 | Antagonist | Douglas Kojetin | 2011 | [82] |
Synthetic | SR9009 SR9011 | Agonist | Laura A Solt | 2012 | [83] |
Synthetic | THIQ1-4 | Agonist | Romain Noel | 2012 | [84] |
Synthetic | GSK2945 GSK0999 GSK5072 GSK2667 | Agonist | Ryan P Trump | 2013 | [85] |
Synthetic | SR12418 | Agonist | Christina Chang | 2019 | [86] |
Natural | Berberine | Agonist | Zi-Yue Zhou | 2020 | [74] |
Natural | Puerarin | Antagonist | Min Chen | 2020 | [87] |