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Fig. 7 | Military Medical Research

Fig. 7

From: Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

Fig. 7

Schematic illustration of Adipsin-induced alleviation of diabetic cardiomyopathy (DCM) by inhibiting Irak2 mitochondrial translocation. Adipsin is secreted by adipose tissues and enters cardiomyocytes. Under HFD conditions, Adipsin enters cardiomyocytes to bind with Irak2 and inhibit its mitochondrial translocation. Reduction in Irak2 entry into mitochondria improves FAO, protects mitochondrial structure and function, reduces myocardial lipid accumulation, further improves cardiac function, and prevents DCM. HFD high-fat diet, OCR oxygen consumption rate, FAO fatty acid β-oxidation, Irak2 interleukin-1 receptor-associated kinase-like 2

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Military Medical Research

ISSN: 2054-9369