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Fig. 5 | Military Medical Research

Fig. 5

From: Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

Fig. 5

ER stress in the pathogenesis of sarcopenia (SP). a Schematic illustration of SP. b FABP3-dependent membrane lipid remodeling and decreased membrane fluidity result in ER stress and inhibit protein translation through the PERK-eIF2α pathway, ultimately leading to SP. eIF2α α-subunit of eukaryotic translation initiation factor 2, ER endoplasmic reticulum, FA fatty acid, FABP3 fatty acid binding protein 3, PERK protein kinase R-like ER kinase

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Military Medical Research

ISSN: 2054-9369