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Fig. 1 | Military Medical Research

Fig. 1

From: Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

Fig. 1

Mechanisms of the UPR (a) and ERAD (b) pathways. ATF4 activating transcription factor 4, ATF6 activating transcription factor 6, BiP binding immunoglobulin protein, CHOP C/EBP homologous protein, eIF2α α-subunit of eukaryotic translation initiation factor 2, ER endoplasmic reticulum, ERAD ER-associated degradation, GADD34 growth arrest and DNA damage-inducible protein 34, IRE1 inositol-requiring enzyme 1, P phosphorylated, PERK protein kinase R-like ER kinase, S1P site-1 membrane proteases, S2P site-2 membrane proteases, XBP-1 X-binding protein 1, XBP-1s spliced XBP-1, Ub ubiquitin

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Military Medical Research

ISSN: 2054-9369