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Fig. 7 | Military Medical Research

Fig. 7

From: Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

Fig. 7

Drp1 is involved in the formation and release of vesicles in ischemia and hypoxia. Drp1-mediated mitochondrial quality imbalance stimulates vesicle secretion and inflammatory cascade activation. MFF on vesicle membranes can recruit cytoplasmic Drp1 to interact with Bcl-xL, resulting in changes in vesicle membrane fluidity. Drp1-binding vesicles can shed Miro1-induced mitochondrial membrane embossments and transform into MDVs. Drp1 dynamin-related protein 1, RIP1 receptor interacting protein 1, ROS reactive oxygen species, Miro1 mitochondrial Rho GTPase 1, Fis1 mitochondrial fission protein 1, TOMM20 translocase of outer mitochondrial membrane 20, MFF mitochondrial fission factor, Bcl-xL B-cell lymphoma-extra large, MDVs mitochondrial-derived vesicles

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Military Medical Research

ISSN: 2054-9369