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Fig. 6 | Military Medical Research

Fig. 6

From: Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

Fig. 6

Drp1 participates in mitochondrial fission and transport by regulating cytoskeleton stability in ischemia and hypoxia. The GTPase domain of Drp1 interacts with FLNa to promote actin aggregation. Shrm4-bound activated Drp1 induces actin bundling to form ER-Mito contacts. The Srv2/Drp1 interaction facilitates Srv2-mediated modulation of actin polymerization on mitochondria. CDK1/cyclin B contributes to Drp1 dissociation from microtubules. Drp1-KLC1 coupling triggers KIF5B displacement from the kinesin-1 complex, increasing its binding to microtubule tracks and, thus, mitochondrial transport. High Drp1 levels exacerbate this mechanism, leading to the repositioning of mitochondria closer to the nucleus after ischemic/hypoxic stress. Drp1 Dynamin-related protein 1, FLNa filamin A, Shrm4 shroom4, ER-Mito endoplasmic reticulum and mitochondria, Srv2 suppressor of Rho3, CDK1 cyclin-dependent kinase 1, KLC1 kinesin light chain 1, KIF5B kinesin family member 5B, ER endoplasmic reticulum, Miro1 mitochondrial Rho GTPase 1

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Military Medical Research

ISSN: 2054-9369