Fig. 5
Drp1 is involved in the regulation of multiple cell death processes in ischemia and hypoxia. â‘ Drp1-BAX apoptosis-positive feedback regulation loop. â‘¡ RIP1-RIP3-Drp1 necroptosis pathway. â‘¢ Drp1-NLRP3 pyroptosis pathway. â‘£ HSP90-Drp1-ACSL4-GPX4 ferroptosis pathway. Drp1 Dynamin-related protein 1, SUMO SUMOylation, HSP90 heat shock protein 90, NOX-1/-4 NADPH oxidase 1 and 4, mPTP mitochondrial permeability transition pore, DDP/TIMM8a deafness dystonia peptide/translocase of inner mitochondrial membrane 8a, Cyto-Drp1 cytoplasmic Drp1, Cyt C cytochrome C, ROS reactive oxygen species, RIP1 receptor interacting protein 1, MLKL mixed lineage kinase domain-like protein, PGAM5 phosphoglycerate mutase 5, NLRP3 NOD-, LRR- and pyrin domain-containing protein 3, GPX4 glutathione peroxidase 4