Fig. 4
From: Elucidating regulatory processes of intense physical activity by multi-omics analysis
Comparative multi-omics analysis of saliva prior and post exercise. a Functional-enrichment analysis of proteins differentially abundant (Student’s t-test P ≤ 0.05) after the exercise session. The enrichment analysis was done with DAVID and the graph is plotted in function of the fold enrichment versus Fisher’s exact test P-values. The colors represent if the pathways were overrepresented in up-regulated or down-regulated proteins, while the circle sizes represent the number of regulated proteins in each pathway. b Boxplot of abundance ratios of abundant intracellular proteins comparing pre- and post-exercise sessions. Diamonds represent outlying data points. c Boxplot of abundance ratios of inflammation and fluid balance comparing pre- and post-exercise sessions. d Saliva lipidomics profile comparing prior and after the exercise session. The bar graph shows the percentage of up and down-regulated (Student’s t-test P ≤ 0.05) species in each lipid class. The stars represent classes of lipids that are significantly enriched (Fisher’s exact test P ≤ 0.05) with differential abundant species, as determined using Lipid MiniOn. Down down-regulated molecule, init. initiation, Up up-regulated molecule, ns non-significant