Fig. 8

Construction process and structure of representative double-responsive hydrogels. a The fabrication of nZnO- and MIC@Pf-Loaded hydrogels and the potential mechanisms of the prepared pH/ROS-responsive hydrogel to facilitate the wound-healing process. Reproduced with permission [89]. Copyright 2022, American Chemical Society. b The structure, pH and glucose-responsive mechanism of the PC hydrogel and its application in diabetic foot ulcers and athletic wound healing. Reproduced with permission [26]. Copyright 2022, American Chemical Society. c The synthesis of injectable pH/temperature-responsive FHE hydrogel (F127/OHA-EPL) with multifunctional properties. Reproduced with permission [66]. Copyright 2019, Ivyspring International. d The preparation and process of a temperature/enzyme-responsive hydrogel with drug release at the wound bed in diabetic mice. Reproduced with permission [70]. Copyright 2018, American Chemical Society. e The formation and drug release process of the MXene-based photo/magnetic-responsive hydrogel. Reproduced with permission [109]. Copyright 2021, Wiley‐VCH GmbH. CNP curcumin nanoparticle, CS-DA-LAG dihydrocaffeic acid and L-arginine cografted chitosan, EPL poly-ε-L-lysine, GO graphene oxide, HA hyaluronic acid, LCST lower critical solution temperature, Met metformin, MMP matrix metalloproteinase, MNPs magnetic nanoparticles, MIC micelles, NIR near-infrared, N-Gel ethylenediamine-modified gelatin, nZnO zinc oxide nanoparticles, ODex oxidized dextran, OHA oxidized hyaluronic acid, PBA phenylboronic acid group, PEGS-BA polyethylene glycol-co-poly(glycerol sebacic acid), Pf paeoniflorin, ROS reactive oxygen species, RT room temperature, AgNPs silver nanoparticles