Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

Table 5 Summaries of proteins associated with the role of EVs in skin wound repair

Macrophage polarization	Proliferation and migration	Angiogenesis	ECM secretion	Reduction of apoptosis	Nerve regeneration	Follicle growth
CD73 [172] TSG-6 [173] CCR2 [174] EDA-FN1 [175]	Wnt4 [94, 95] Wnt11 [142] Jagged1 [101] CD73 [172] Wnt3a [176] TGF-β1 [177]	Wnt3a [176] NG2 [178] PDGF-D [179] VEGF [180] SDF1/CXCL12 [181] Wnt4 [94]	CD73 [172]	Wnt4 [94] MIF [182]	NGF [146] CNTF [146] BDNF [146] GDNF [146] HDACs [147] APP [147] ITGB1 [147]	Wnt3a [142] Wnt11 [142]

EVs extracellular vesicles, TSG-6 tumor necrosis factor alpha-stimulated gene 6, CCR2 C-C motif chemokine receptor-2, EDA-FN1 alternatively spliced domain A-containing fibronectin 1, NG2 neural/glial antigen 2, PDGF-D platelet-derived growth factor D, SDF1 stromal derived factor 1, MIF macrophage migration inhibitory factor, CD cluster of differentiation, Wnt wingless/integrated, TGF-β transforming growth factor-β, VEGF vascular endothelial growth factor, CXCL C-X-C motif chemokine ligand, NGF nerve growth factor, CNTF ciliary neurotrophic factor, BDNF brain-derived neurotrophic factor, GDNF glial cell line-derived neurotrophic factor, HDAC histone deacetylase, APP amyloid-beta A4 protein, ITGB integrin beta

ISSN: 2054-9369