Fig. 4
From: Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
The CRISPR/Cas system and gene editing mechanism. a CRISPR/Cas locus in the bacterial genome with associated transcription and translation products. b CRISPR/Cas engineered for site-specific gene editing. c Editing of dsDNA using CRISPR/Cas12a and CRISPR/Cas9 respectively. CRISPR/Cas clustered regularly interspaced short palindromic repeats/CRISPR-associated protein, dsDNA double strands DNA, crRNA CRISPR RNA, TracrRNA trans-activating CRISPR RNA, sgRNA single-guide RNA, PAM protospacer adjacent motif