Fig. 2
From: Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
A graphical illustration of how oncogenic and tumor suppressor miRNAs are regulated during tumorigenic events. a When oncogenic miRNAs are expressed at higher levels in malignant cells, tumor suppressor gene expression is lowered either as a result of mRNA degradation or hypermethylation. b Oncogenic miRNA expression may be increased by decreasing the expression level of tumor suppressor miRNAs. Both oncogenic and tumor suppressor miRNAs contribute to tumorigenesis by promoting a variety of malignant phenotypes, including cell development, anti-apoptotic activity, invading, angiogenic, and spreading. RISC RNA-induced silencing complex, ORF open reading frame