Fig. 6
From: Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Structure of ROS-related probes and their applications. a Illustration of the generation of endogenous HNO and H2Sn in living cells. b Representative in vivo NIR fluorescence images visualizing HNO in a gouty arthritis rat model. a and b were reproduced with permission from ref. [99]. Copyright (2019) Royal Society of Chemistry. c Schematic illustration of the interference-free ·OH detection mechanism of the csEr-Cy nanoprobe and its application in vivo. Reproduced with permission from ref. [100]. Copyright (2022) American Chemical Society. d Illustration of the development of a nanoplatform with two-photon imaging and serial ROS sensitivity. Reproduced with permission from ref. [101]. Copyright (2022) American Chemical Society. ROS reactive oxygen species, NO nitroxyl, H2Sn polysulfide, ·OH hydroxyl radical, 3-MST 3-mercaptopyruvate sulfurtransferase, CSE cystathionine γ-lyase, CBS cystathionine-β-synthase, HE hematoxylin-eosin, HNO nitroxyl, GA gouty arthritis, a.u. arbitrary unit, NTf2 bis(trifluoromethanesulfonyl)imide, H2S hydrogen sulfide, NOC-5 3-[2-hydroxy-1-(1-methylethyl)-2-nitrosohydrazinyl]-1-propanamine, iNOS inducible nitric oxide synthase