Fig. 3
From: Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
69Structure and application of NIR fluorescent probes for detecting HClO. Structure and response mechanism of the probes, NFL-X (a), Lyso-TP-HClO (b) and PTA (d). c Monitoring of response of HClO-induced RA via Lyso-TP-HClO under the treatment with λ-carrageenan or MTX. (1) left hindlimb and (2) right hindlimb. Reproduced with permission from ref. [69]. Copyright (2021) Elsevier B.V. e In vivo NIR-II fluorescence imaging of endogenous HClO production in RA mice. NIR-II fluorescence images in 5, 15, and 30 min after the injection of developed probe (PTA). Reproduced with permission from ref. [72]. Copyright (2021) American Chemical Society. HClO hypochlorous acid, NIR near-infrared, MTX methotrexate, RA rheumatoid arthritis, NIR-II second near-infrared region