CR-mimetics | Animal/dose | Duration | References |
---|---|---|---|
Resveratrol | 2 months old mice, 4.9 mg/(kg·d) | 8 months | [24] |
10 months old mice, 20 mg/(kg·d) | 4 d | [25] | |
14 months old mice, 50 mg/(kg·d) | 16 months | [26] | |
Quercetin | 1 year old diabetic Zucker Diabetic Fatty rats, 20 mg/(kg·d) | 6 weeks | [27] |
8Â weeks old dystrophin-deficient mice, diet with 0.2% quercetin | 8Â months | [28] | |
Curcumin | 26–28 months old rats, 50 mg/(kg·d) | 2 months | [29] |
EGCG | 16 months old mice, 50 mg/(kg·d) | 8 weeks | [30] |
24–26 months old mice, 200 mg/(kg·d) | 1 month | [31] | |
Spermidine | 4Â months old mice, 3Â mmol/L in drinking water | 26Â months | [32] |
18Â months old mice, 3Â mmol/L in drinking water | 6Â months | [33] | |
27–29 months old mice, 3 mmol/L in drinking water | 4 weeks | [34] | |
7Â weeks old Dahl salt-sensitive rats, 3Â mmol/L in drinking water | 12Â weeks | [32] | |
22–24 months old rats, 10 mg/(kg·d) | 6 weeks | [35] |