Fig. 4

Gradual recovery of the plasma metabonomics. a PCA, PLD-DA and OPLS-DA showed the gradual recovery of plasma metabonomics. b Average compositions and relative abundance of the metabonomics community among the three groups. c In the process of recovery, the key metabolites whose abundance gradually increased or decreased were identified. d Sphingosine-1-phosphate increased significantly during the recovery process. e Annotated metabolites were analyzed and compared between CPR1 and CPR0. f Annotated metabolites were analyzed and compared between CPR1 and HC.^***P < 0.001, pairwise comparisons among the three groups. CPR0 confirmed patients recover at discharge, CPR1 confirmed patients recover 1 year, HC healthy control, PCA principal component analysis, PLS-DA partial least squares discrimination analysis, OPLS-DA orthogonal partial least squares discrimination analysis