Table 1 Top 30 significantly up-regulated DE genes and GO annotations after NBXH treatment
Gene symbol | Fold change in DE | Gene ontology annotations | ||||
|---|---|---|---|---|---|---|
NBXH group vs. TB model group | TB model group vs. normal control group | JHW vs. TB model group | BP | CC | MF | |
Rho | 4.07 | NO | NO | NO | NO | NO |
Sap25 | 3.13 | NO | NO | NO | NO | NO |
Srp54a | 2. 50 | − 1.16 | 3.25 | SRP-dependent cotranslational protein targeting to membrane; response to drug | Nuclear speck | GTP binding, GTPase activity, drug binding, etc. |
Mouse_newGene_24952 | 2.06 | −1.17 | 2.87 | NO | NO | NO |
Gm38394 | 1.89 | −1.35 | NO | NO | NO | Transcription factor activity, sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein dimerization activity |
Mouse_newGene_25840 | 1.76 | −3.91 | NO | NO | NO | NO |
Mouse_newGene_3409 | 1.64 | −3.60 | NO | Humoral immune response mediated by circulating immunoglobulin, positive regulation of peptidyl-tyrosine phosphorylation, early endosome to late endosome transport, etc. | Immunoglobulin complex, circulating, external side of plasma membrane, B cell receptor complex | Antigen binding, transmembrane signaling receptor activity |
Mouse_newGene_21033 | 1.51 | −1.37 | NO | NO | NO | NO |
Mouse_newGene_34719 | 1.37 | NO | NO | NO | NO | GTPase activator activity |
Mouse_newGene_1240 | 1.28 | −1.17 | 1.16 | Negative regulation of peptidase activity | Extracellular region | Ligase activity, serine-type endopeptidase inhibitor activity |
Mouse_newGene_4366 | 1.26 | NO | 1.63 | NO | NO | NO |
Tmem229a | 1.26 | NO | NO | NO | NO | NO |
Mouse_newGene_3520 | 1.24 | −0.91 | 0.98 | Response to hormone, positive regulation of stress-activated MAPK cascade, negative regulation of microtubule depolymerization, etc. | Cytoplasmic microtubule | Ligase activity, ubiquitin protein ligase binding |
Rapgef5 | 1.23 | −1.28 | 0.92 | Small gtpase-mediated signal transduction, positive regulation of gtpase activity |  | GTP-dependent protein binding |
Mapk14 | 1.22 | NO | 0.75 | Lipopolysaccharide-mediated signaling pathway, response to muscle stretch, etc. | Spindle pole | Protein phosphatase binding, protein c-terminus binding |
Slc5a1 | 1.17 | NO | NO | NO | NO | NO |
Kcna2 | 1.16 | −2.43 | NO | NO | NO | NO |
Mouse_newGene_31701 | 1.14 | NO | 0.98 | Response to oxidative stress, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, etc. | Lamellipodium, CD95 death-inducing signaling complex, growth cone, etc. | Rac GTPase binding, GTPase activator activity, diacylglycerol choline phosphotransferase activity, etc. |
Crispld2 | 1.13 | NO | NO | Lung development, face morphogenesis, extracellular matrix organization | Proteinaceous extracellular matrix, transport vesicle | Heparin binding |
Mouse_newGene_25226 | 1.13 | −1.03 | NO | NO | NO | NO |
Plekhs1 | 1.11 | −0.86 | NO | NO | NO | NO |
Pcdhgb7 | 1.11 | NO | NO | Nervous system development, synapse organization, cell-cell signaling, etc. | NO | NO |
Zfp273 | 1.10 | −1.91 | NO | NO | NO | NO |
Gpr27 | 1.09 | NO | 1.33 | Positive regulation of insulin secretion involved in cellular response to glucose stimulus | NO | NO |
Mouse_newGene_25949 | 1.09 | −1.81 | 1.05 | Response to lead ion | Growth cone, filopodium | Cholesterol binding |
Mouse_newGene_12272 | 1.09 | −1.33 | NO | NO | NO | NO |
Jmjd8 | 1.09 | −0.88 | 0.73 | NO | NO | NO |
Mouse_newGene_6388 | 1.08 | −2.82 | NO | NO | NO | NO |
Arhgap19 | 1.07 | −1.30 | NO | Signal transduction | NO | GTPase activator activity |
Zkscan7 | 1.06 | −1.75 | NO | NO | NO | NO |