Table 1 Blood eosinophilia classification, modified from Valent et al. [5]
From: A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia
Classification | Definition |
|---|---|
Secondary reactive eosinophilia | Underlying condition/disease in which eosinophils are considered non-clonal cells; eosinophilia considered cytokine driven in most cases |
Primary neoplastic eosinophilia | Underlying stem cell, myeloid, or eosinophilic neoplasm, as classified by WHO criteria; eosinophils considered neoplastic cells |
Hereditary eosinophilia | Pathogenesis unknown; familial clustering, no signs or symptoms of hereditary immunodeficiency, and no evidence of a reactive or neoplastic condition/disorder underlying eosinophilia |
HE of undetermined significance | No underlying cause of eosinophilia, no family history, no evidence of a reactive or neoplastic condition/disorder underlying eosinophilia, and no end-organ damage attributable to eosinophilia |